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CD304 (Neuropilin-1), clone: XML1Y1, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-3042-80

Additional Details : Weight : 0.09500kg

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Product Code. 15507446

  • 1110.00 SEK / 25µg


Estimated Shipment date
from Supplier 30-04-2019
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Description

Description

Description: The monoclonal antibody XML1Y1 recognizes CD304 (Neuropilin-1), a type 1 transmembrane glycoprotein present on the surface of multiple cell types, including: regulatory T cells (Tregs), NKT cells, DC, certain types of stem cells, neurons, endothelial cells, and some neoplastic cells. Neuropilin-1, in complex with plexins, serves as a co-receptor for type 3 semaphorins in growing neurons. It is also involved in the process of angiogenesis being a part of a functional receptor for VEGF in endothelial cells. In mouse Neuropilin-1 is expressed on thymus-derived natural Tregs but not peripherally induced Treg cells. In addition, transient expression on recently activated non-regulatory T cells has been observed. Neuropilin-1 has been used as a marker of recent thymic emigrants in the mouse iNKT cell population. It has been shown that Neuropilin-1 forms a complex with TGF beta receptors, activating TGF beta latent form (LAP-TGF beta 1) and augmenting canonic Smad2/3 signaling.This XML1Y1 antibody recognizes neuropilin-1 isoforms 1 and 2.Applications Reported: This XML1Y1 antibody has been reported for use in immunohistochemical staining of frozen tissue sections, and immunocytochemistry.Applications Tested: This XML1Y1 antibody has been tested by immunohistochemistry of acetone-fixed frozen tissue sections and can be used at less than or equal to 1 ug/mL. This XML1Y1 antibody has been tested by immunocytochemistry of methanol-fixed bEND3 cells and can be used at less than or equal to 1 ug/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

CD304 (Neuropilin-1)
Monoclonal
0.5mg/mL
PBS with 0.09% sodium azide; pH 7.2
P97333
BDCA4, CD304, NP1, NRP, VEGF165R, neuropilin-1, transmembrane receptor, vascular endothelial cell growth factor 165 receptor
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Murine
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen)
XML1Y1
Unconjugated
Nrp1
Liquid
Nrp1
IgG2a, kappa, kappa
25μg
Store at 2-8°C.
Primary
18186
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