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  6. Invitrogen™ CD326 (EpCAM) Monoclonal Antibody (G8.8), PE-eFluor™ 610, eBioscience™, Invitrogen™

Invitrogen™ CD326 (EpCAM) Monoclonal Antibody (G8.8), PE-eFluor™ 610, eBioscience™, Invitrogen™

Produktkod. p-7218756
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25 μg
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Produktkod. Kvantitet
17104103 25 μg
17114103 100 μg
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Produktkod. 17104103 Leverantör Invitrogen™ Leverantörsnummer 61579180

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Beskrivning

Rat Monoclonal Antibody

The G8.8 MAb reacts with the 40 kDa protein mouse EpCAM (epithelial cellular adhesion molecule), also known as EGP40 (epithelial glycoprotein 40), 17-1A antigen, TACSTD1 (tumor-associated calcium signal transducer 1), and CD326. The immunogen used to generate the G8.8 antibody was the TE-71 thymic epithelial cell line. CD326 is expressed on the majority of epithelial cells, and is considered a pan-carcinoma antigen. CD326 mediates calcium-independent, homophilic, cell-cell adhesion and may function as a growth factor receptor. The antigen is being used as a target for immunotherapy treatment of human carcinomas. CD326 binds LAIR-1 (CD305) and LAIR-2 (CD306) to inhibit cellular activation and inflammation. This epithelial glycoprotein is now recognized as having an important role in tumor biology.

Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA) is a transmembrane glycoprotein expressed in the epithelium with a molecular weight of approximately 40 kDa, which functions as an epithelial cell adhesion molecule. Ep-CAM functions as a homotypic calcium-independent cell adhesion molecule, and has a direct impact on cell cycle, proliferation and metabolism of epithelial cells and fibroblasts due to its ability to rapidly induce the proto-oncogene c-myc and the cell cycle regulating genes cyclin A and E. Ep-CAM mediates Ca2+-independent homotypic interactions. Formation of Ep-CAM-mediated adhesions have a negative regulatory effect on adhesions mediated by classic cadherins, which may have strong effects on the differentiation and growth of epithelial cells. Ep-CAM overexpression was suggested to be associated with enhanced epithelial proliferation. Ep-CAM is highly expressed in human carcinomas, and is a marker for tumors of epithelial lineage. Ep-CAM is expressed on baso-lateral cell surface in most simple epithelia and many carcinoma types. Also, Ep-CAM reportedly distinguishes adenocarcinomas from pleural mesotheliomas.
TRUSTED_SUSTAINABILITY

Specifikationer

Antigen CD326 (EpCAM)
Användningsområden Flow Cytometry
Klassificering Monoclonal
Klona G8.8
Koncentration 0.2 mg/mL
Konjugera PE-eFluor 610
Formulering PBS with 0.09% sodium azide; pH 7.2
Gen EPCAM
Genaccessionsnr. Q99JW5
Gene Alias adenocarcinoma-associated antigen; CD326; cell surface glycoprotein Trop-1; DIAR5; EGP; EGP-2; EGP314; EGP40; EPCAM; Ep-CAM; EpCAM1; epithelial cell adhesion molecule; Epithelial cell surface antigen; Epithelial glycoprotein; Epithelial glycoprotein 314; ESA; GA733-2; gp40; hEGP314; HNPCC8; human epithelial glycoprotein-2; KS 1/4 antigen; KS1/4; KSA; Ly74; lymphocyte antigen 74; M1S2; M4S1; major gastrointestinal tumor-associated protein GA733-2; mEGP314; membrane component, chromosome 4, surface marker (35kD glycoprotein); MIC18; MK-1; panepithelial glycoprotein 314; protein 289A; Protein D5.7A; Tacsd1; Tacstd1; TROP1; Trop-1 protein; Tumor-associated calcium signal transducer 1
Gensymboler EPCAM
Värd art Rat
Reningsmetod Affinity chromatography
Kvantitet 25 μg
Regulatorisk status RUO
Primär eller sekundär Primary
Gen-ID (Entrez) 17075
Målarter Mouse
Innehåll och lagring 4°C, store in dark, DO NOT FREEZE!
Produkttyp Antibody
Form Liquid
Isotyp IgG2a κ
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