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CD335 (NKp46) Monoclonal Antibody (29A1.4), Biotin, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

578.00 SEK - 1580.00 SEK

Specifications

Antigen CD335 (NKp46)
Clone 29A1.4
Concentration 0.5 mg/mL
Applications Flow Cytometry
Classification Monoclonal
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15517336
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Affymetrix eBioscience
13-3351-82
100 μg
1580.00 SEK
100µg
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15507336
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Affymetrix eBioscience
13-3351-80
25 μg This item is currently unavailable or has been discontinued.
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Description

Description

Description: The monoclonal antibody 29A1.4 recognizes mouse NKp46, also known as CD335. CD335, a member of the natural cytotoxicity receptor (NCR) family, is a glycoprotein with 2 Ig-like domains and a short cytoplasmic tail. Expression of CD335 is uniquely found on NK cells (including immature NK cells, defined as DX5- CD3-, and thereby allowing discrimination between NKT cells and NK cells (NKp46+, CD3-). Furthermore, unlike many of the NK markers which also stain NKT cells, staining with 29A1.4 is not strain specific. Staining has been shown on C57Bl/6, SJL, CBA/CA and BALB/C strains. NKp46 has been shown to play a role in NK cell-mediated lysis of several tumor cells and pathogen-infected cell lines. The 29A1.4 monoclonal antibody has been shown to activate NK cells in vitro. The 29A1.4 monoclonal antibody does not deplete NK cells in vivo. Applications Reported: This 29A1.4 antibody has been reported for use in flow cytometric analysis. Applications Tested: This 29A1.4 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.125 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Filtration: 0.

NKp46 (CD335, NCR1, ) is a cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. NKp46 consists of two Ig-like domains assembled to leukocyte immunoglobulin-like (LIR) and killer inhibitory receptors (KIR).
Specifications

Specifications

CD335 (NKp46)
0.5 mg/mL
Monoclonal
Liquid
RUO
Q8C567
IgG2a κ
Affinity chromatography
Antibody
29A1.4
Flow Cytometry
Biotin
Rat
Mouse
17086
Primary
4° C, store in dark, DO NOT FREEZE!
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