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CD335 (NKp46) Monoclonal Antibody (29A1.4), Biotin, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
578.00 SEK - 1580.00 SEK
Specifications
Antigen | CD335 (NKp46) |
---|---|
Clone | 29A1.4 |
Concentration | 0.5 mg/mL |
Applications | Flow Cytometry |
Classification | Monoclonal |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15517336
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Affymetrix eBioscience
13-3351-82 |
100 μg |
1580.00 SEK
100µg |
In Stock Log in to see stock. |
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15507336
|
Affymetrix eBioscience
13-3351-80 |
25 μg |
This item is currently unavailable or has been discontinued. View the product page for possible alternatives. |
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Description
Description: The monoclonal antibody 29A1.4 recognizes mouse NKp46, also known as CD335. CD335, a member of the natural cytotoxicity receptor (NCR) family, is a glycoprotein with 2 Ig-like domains and a short cytoplasmic tail. Expression of CD335 is uniquely found on NK cells (including immature NK cells, defined as DX5- CD3-, and thereby allowing discrimination between NKT cells and NK cells (NKp46+, CD3-). Furthermore, unlike many of the NK markers which also stain NKT cells, staining with 29A1.4 is not strain specific. Staining has been shown on C57Bl/6, SJL, CBA/CA and BALB/C strains. NKp46 has been shown to play a role in NK cell-mediated lysis of several tumor cells and pathogen-infected cell lines. The 29A1.4 monoclonal antibody has been shown to activate NK cells in vitro. The 29A1.4 monoclonal antibody does not deplete NK cells in vivo. Applications Reported: This 29A1.4 antibody has been reported for use in flow cytometric analysis. Applications Tested: This 29A1.4 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.125 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Filtration: 0.
NKp46 (CD335, NCR1, ) is a cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. NKp46 consists of two Ig-like domains assembled to leukocyte immunoglobulin-like (LIR) and killer inhibitory receptors (KIR).Specifications
CD335 (NKp46) | |
0.5 mg/mL | |
Monoclonal | |
Liquid | |
RUO | |
Q8C567 | |
IgG2a κ | |
Affinity chromatography | |
Antibody |
29A1.4 | |
Flow Cytometry | |
Biotin | |
Rat | |
Mouse | |
17086 | |
Primary | |
4° C, store in dark, DO NOT FREEZE! |
For Research Use Only.