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CD34 Rat anti-Mouse, FITC, Clone: RAM34, eBioscience™

Rat Monoclonal Antibody

782.00 SEK - 2385.00 SEK

Specifications

Antigen CD34
Clone RAM34
Target Species Mouse
Conjugate FITC
Isotype IgG2a, kappa
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Products 3
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15248069 Affymetrix eBioscience
11-0341-81
50 μg 782.00 SEK
50µg View alternative products
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EU Stock 5
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15258069 Affymetrix eBioscience
11-0341-82
100 μg 1190.00 SEK
100µg View alternative products
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EU Stock 12
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15268069 Affymetrix eBioscience
11-0341-85
500 μg 2385.00 SEK
500µg View alternative products
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EU Stock 13
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Description

Description

Note: When staining with the RAM34 antibody an incubation time of 90 minutes is recommended to obtain the optimal signal to noise ratio. For more detailed information on staining with RAM34, please refer to Ema et al., listed under References. Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser. Filtration: 0.2 μm post-manufacturing filtered. CD34 is a highly glycosylated monomeric with a molecular weight range of 111-115 kDa surface protein that is present on many stem cell populations. CD34 is a stem cell marker although its expression on human hematopoietic stem cells is reversible. CD34 may serve as a surface receptor that undergoes receptor-mediated endocytosis and regulates adhesion, differentiation and proliferation of hematopoietic stem cells and other progenitors. CD34 expression is likely to represent a specific state of hematopoietic development that may have altered adhering properties with expanding and differentiating capabilities in both in vitro and in vivo conditions. CD34 is possibly an adhesion molecule with a putative role for mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Further, CD34 could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C suggesting a putative role in signal transduction. Diseases associated with CD34 dysfunction include dermatofibrosarcoma and neurofibroma.
Specifications

Specifications

CD34
Mouse
IgG2a, kappa
Monoclonal
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!
RAM34
FITC
Flow Cytometry
Primary
Monoclonal
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
RUO

For Research Use Only.