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CD4 Monoclonal Antibody (YKIX302.9), FITC, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

1072.00 SEK - 2835.00 SEK

Specifications

Antigen CD4
Clone YKIX302.9
Applications Flow Cytometry
Classification Monoclonal
Conjugate FITC
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15596546
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Affymetrix eBioscience
11-5040-42
100 Tests
2835.00 SEK
100 tests
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15586546
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Affymetrix eBioscience
11-5040-41
25 Tests This item is currently unavailable or has been discontinued.
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Description

Description

Description: The YKIX302.9 monoclonal antibody reacts with canine CD4, a cell surface receptor expressed on a majority of thymocytes, a subpopulation of mature T cells and dendritic cells. In dogs, CD4 is also highly expressed on neutrophils. CD4 binds to MHC class II on the surface of antigen presenting cells and plays an important role in T cell development and homeostasis. This YKIX302.9 monoclonal antibody has been reported to block MHC II-restricted T cell responses in vivo and in vitro. Applications Reported: This YKIX302.9 antibody has been reported for use in flow cytometric analysis. Applications Tested: This YKIX302.9 antibody has been pre-titrated and tested by flow cytometric analysis of normal canine peripheral blood cells. This can be used at 5 μL (0.125 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser. Filtration: 0.2 μm post-manufacturing filtered.

The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].
Specifications

Specifications

CD4
Flow Cytometry
FITC
RUO
P33705
IgG2a κ
Affinity chromatography
CD4
YKIX302.9
Monoclonal
Rat
Canine
CD4
Primary
Antibody
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Product Certifications

For Research Use Only.