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CD43 Mouse anti-Human, FITC, Clone: eBio84-3C1 (84-3C1), eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 11-0439-42

Additional Details : Weight : 0.23750kg

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Product Code. 15506406

  • 1548.00 SEK / 100 tests


Estimated Shipment date
from Supplier 25-04-2019
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Description

Description

CD43 (leukosialin, sialophorin) is a transmembrane mucin-like protein with high negative charge, expressed on the surface of most hematopoietic cells. CD43 contributes to a repulsive barrier that interferes with cellular adhesion, however, in certain cases also promotes leukocyte aggregation. By interaction with actin-binding proteins ezrin and moesin CD43 plays a regulatory role in remodeling T-cell morphology and regulates cell-cell interactions during lymphocyte traffic. CD43 signaling both enhances LFA-1 adhesiveness and counteracts LFA-1 induction via other receptors. Expression of CD43 causes induction of functionally active tumor suppressor p53 protein, but in case of p53 and ARF deficiency CD43 promotes tumor proliferation and viability. CD43 appears to be an important modulator of leukocyte functions. Diseases associated with CD43 dysfunction include Wiscott-Aldrich Syndrome and Adenoid Basal Cell Carcinoma.
Specifications

Specifications

CD43
Monoclonal
5 μL/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
P16150
CD43, GALGP, GPL115, LSN, galactoglycoprotein, leukocyte sialoglycoprotein, leukosialin, sialophorin gpL115, leukosialin, CD43
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
eBio84-3C1 (84-3C1)
FITC
SPN
Liquid
SPN
IgG1, kappa
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
6693
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