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STEMCELL Technologies CD437

Produktkod. 17160112
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5 mg
25 mg
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5mg
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17160112 5 mg 5mg
17170112 25 mg -
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Produktkod. 17160112 Leverantör STEMCELL Technologies Leverantörsnummer 72722

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Beskrivning

Retinoid pathway activator; Activates retinoic acid receptor (RAR)

  • CD437 is the prototypical adamantyl arotinoid of the retinoid-related molecule family that acts as a selective agonist of retinoic acid receptor (RAR)γ (Kd = 6.5 μM, 2.5 μM, and 77 nM for RARα, β, and γ, respectively; Bernard et al.; Pérez-Rodríguez et al.)
  • Increases speed and number of pre-induced pluripotent stem (iPS) cell colonies generated from mouse embryonic fibroblasts (MEFs) transfected with Oct4, Sox2, c-Myc, and Klf4 (Wang et al.)
  • Induces cell cycle arrest and apoptosis in a variety of cancer cells (Fontana and Rishi; Jin et al.; Li et al.; Valli et al.)
  • Decreases mRNA expression of squamous differentiation markers cytokeratin 1, involucrin, and SPR1 in the human head and neck squamous cell carcinoma cell line, UMSCC22B (Sun et al.)

Specifikationer

CAS 125316-60-1
Synonym AHPN
Kvantitet 5 mg
Molekylformel C27H26O3
Renhet ≥95%
Produkttitel
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