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CD45RO, clone: UCHL1, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-0457-82

Additional Details : Weight : 0.01000kg

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Product Code. 15276977

  • 918.00 SEK / 100µg


EU Stock 1
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Description

Description

CD45RO (UCHL1, ubiquitin carboxyl terminal esterase L1) is the shortest isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RO is expressed on macrophages, CD8+ T cells, activated T cells and myeloma cells. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.
Specifications

Specifications

CD45RO
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P08575
B220, CD45, CD45R, GP180, LCA, LY5, T200
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry, Immunohistochemistry
UCHL1
Unconjugated
PTPRC
Liquid
PTPRC
IgG2a, kappa
100 μg
4° C
Primary
5788
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