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  6. Invitrogen™ CD49b (Integrin alpha 2) Monoclonal Antibody (DX5), Biotin, eBioscience™, Invitrogen™

Invitrogen™ CD49b (Integrin alpha 2) Monoclonal Antibody (DX5), Biotin, eBioscience™, Invitrogen™

Produktkod. 15299959
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Produktkod. 15299959 Leverantör Invitrogen™ Leverantörsnummer 13597185

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Beskrivning

Rat Monoclonal Antibody

Description: The DX5 monoclonal antibody reacts with CD49b, an antigen expressed on a majority of mouse natural killer cells and a subset of T cells. DX5 reacts with all strains of mouse tested including the most commonly used strains, BALB/c, C57BL/6, C3H, CBA, DBA, AKR, SJL and 129. Simultaneous staining of C57BL/6 spleen cells with anti-NK1.1 mAb (PK136) and DX5 reveals coexpression of both markers by a majority of cells as well as presence of small populations of DX5+PK136- and DX5-PK136+ cells. Applications Reported: The DX5 antibody has been reported for use in flow cytometric analysis. Applications Tested: The DX5 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Filtration: 0.2 μm post-manufacturing filtered.

CD49b (Integrin alpha 2, Integrin alpha 2 chain, VLA-2 alpha chain, HM alpha 2) is a member of the integrin family. It is a glycoprotein with molecular weight of 150 kD, and it complexes with CD29 (Integrin beta 1) to form the heterodimeric integrin VLA-2 (integrin alpha 2 beta 1, or GPIa/IIa) complex. VLA-2 is an extracellular receptor for laminin, collagen, and fibronectin, and interaction with its ligands results in the activation of intracellular signaling pathways. It has reported roles in VEGF-induced angiogenesis in vivo, as well as adhesion and lymphocyte activation. CD49b is expressed by NK cells, NK-T cells, monocytes, platelets, and epithelial cells. It is also expressed on adaptive immune cells such as T and B cells, specifically on a subset of CD4+ T cells in the spleen, on intraepithelial and lamina propria lymphocytes in the intestine, as well as on a population of peripheral CD4+ type 1 T regulatory (Tr1) cells that co-express LAG-3.
TRUSTED_SUSTAINABILITY

Specifikationer

Antigen CD49b (Integrin alpha 2)
Användningsområden Flow Cytometry
Klassificering Monoclonal
Klona DX5
Koncentration 0.5 mg/mL
Konjugera Biotin
Formulering PBS with 0.09% sodium azide; pH 7.2
Gen Itga2
Genaccessionsnr. Q62469
Gene Alias alpha 2 subunit of VLA-2 receptor; BDPLT9; BR; CD49 antigen-like family member B; CD49B; Collagen receptor; DX5; GPIa; HPA-5; human platelet alloantigen system 5; integrin alpha 2; integrin alpha-2; integrin subunit alpha 2; integrin, alpha 2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Itga2; platelet antigen Br; platelet glycoprotein GPIa; platelet membrane glycoprotein Ia; very late activation protein 2 receptor, alpha-2 subunit; VLA-2; VLA2 receptor; VLA-2 receptor, alpha 2 subunit; VLA-2 subunit alpha; VLAA2
Gensymboler Itga2
Värd art Rat
Reningsmetod Affinity chromatography
Kvantitet 500 μg
Regulatorisk status RUO
Primär eller sekundär Primary
Gen-ID (Entrez) 16398
Målarter Mouse
Innehåll och lagring 4°C, store in dark, DO NOT FREEZE!
Produkttyp Antibody
Form Liquid
Isotyp IgM κ
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For Research Use Only.

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