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CD54 (ICAM-1) Mouse anti-Human, Clone: HA58, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-0549-80

Additional Details : Weight : 0.01000kg

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Product Code. 15237027

  • 433.00 SEK / 25µg


Estimated Shipment
02-11-2020
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Description

Description

ICAM-1 (CD54) is an 85-110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. ICAM-1 has 7 potential N-linked glycosylation sites and shares considerable amino acid sequence homology with ICAM-3 (CD50) and ICAM-2 (CD102). ICAM-1 binds to integrins of type CD11a/CD18 (leukocyte adhesion molecule, LFA-1), or CD11b/CD18 (Mac-1) and is exploited by Rhinovirus as a receptor. ICAM-1 is expressed by activated endothelial cells and detected on epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase upon inflammation. ICAM-1 is also detected in some carcinoma and melanoma cells. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes.
Specifications

Specifications

CD54 (ICAM-1)
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P05362
BB2, P3.58, ICAM-1, cell surface glycoprotein P3.58, intercellular adhesion molecule 1, human rhinovirus receptor, major group rhinovirus receptor
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry, Functional Assay, Immunohistochemistry, Neutralization, Western Blot
HA58
Unconjugated
ICAM1
Liquid
ICAM1
IgG1, kappa
25 μg
4° C
Primary
3383
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