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CD54 (ICAM-1) Monoclonal Antibody (R6.5), eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Brand: Affymetrix eBioscience BMS1011
Additional Details : Weight : 0.09500kg
Description
Description: Anti-ICAM-1 Monoclonal Antibody R6.5, a murine IgG2a mAb to the human ICAM-1, inhibits leukocyte adhesion to the vascular endothelium, thereby decreasing leukocyte extravasation and inflammatory tissue injury. Intercellular Adhesion Molecule-1 (ICAM-1) is a member of the immunoglobulin supergene family and functions as a ligand for the Lymphocyte Function-Associated Antigen-1 (LFA-1), an alpha-betacomplex that is a member of the leukocyte integrin family of cell-cell and cell-matrix receptors. ICAM-1 is a single-chain glycoprotein with a polypeptide core of 55 kD that can be expressed on non-hematopoietic cells of many lineages such as vascular endothelial cells, thymic epithelial cells, other epithelial cells and fibroblasts and on hematopoietic cells such as tissue macrophages, mitogen-stimulated T-lymphoblasts, germinal center B cells and dendritic cells in tonsils, lymph nodes and Peyer's patches. ICAM-1 is inducible on fibroblasts and endothelial cells by inflammatory mediators such as IL-1, TNF and IFN-gamma within few hours and is correlated to the infiltration of lymphocytes into inflammatory lesions. ICAM-1 seems to be the initial marker of inflammatory reactions and is expressed prior to, and to a greater extent than is HLA-DR. sICAM-1 serum levels were found elevated in acute renal graft rejection, insulin-dependent diabetis mellitus, anterior uveitis and in allergic inflammation. Applications Tested: ELISA.
CD54 (ICAM-1) Monoclonal antibody specifically detects CD54 (ICAM-1) in Human samples. It is validated for ELISA.Specifications
| CD54 (ICAM-1) | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with no preservative; pH 7.2-7.4 | |
| P05362 | |
| ICAM1 | |
| Rec. Human ICAM-1 | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG2a |
| ELISA | |
| R6.5 | |
| Unconjugated | |
| ICAM1 | |
| BB2; CD54; cell surface glycoprotein P3.58; Human rhinovirus receptor; ICAM; Icam1; ICAM-1; ICAM-1; CD54 homolog; Intercellular adhesion molecule 1; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; intercellular adhesion molecule-1; intercellular adhesion molecule-1 precursor; Ly 47; Ly-47; major group rhinovirus receptor; MALA2; MALA-2; MyD10; P3.58; sCD54; soluble CD54; Surface antigen of activated B cells | |
| Mouse | |
| Affinity chromatography | |
| RUO | |
| 3383 | |
| -20°C | |
| Liquid |
For Research Use Only.