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CD59 Antibody (MACIF/1193) - IHC-Prediluted, Novus Biologicals™

Produktkod. 18122429 Handla allt Bio Techne Produkter
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7 mL
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18122429 7 mL
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Produktkod. 18122429 Leverantör Novus Biologicals Leverantörsnummer NBP248467

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Beskrivning

Mouse Monoclonal Antibody

CD59 Monoclonal specifically detects CD59 in Human, Baboon (Negative), Equine (Negative) samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.
TRUSTED_SUSTAINABILITY

Specifikationer

Antigen CD59
Användningsområden Immunohistochemistry (Paraffin)
Klassificering Monoclonal
Klona MACIF/1193
Konjugera Unconjugated
Utspädning Immunohistochemistry-Paraffin
Formulering 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Alias 16.3A5, 1F5, 1F5 antigen, 20 kDa homologous restriction factor, CD59 antigen, CD59 antigen, complement regulatory protein, CD59 glycoprotein, CD59 molecule, complement regulatory protein, EJ16, EJ30, EJ30, EL32 and G344), EL32, FLJ38134, FLJ92039, G344, HRF20, HRF-20, human leukocyte antigen MIC11, Ly-6-like protein, lymphocytic antigen CD59/MEM43, MACIF, MAC-inhibitory protein, MAC-IP, MEM43, MEM43 antigen, membrane attack complex (MAC) inhibition factor, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, MGC2354, MIC11MSK21, MIN1, MIN2, MIN3, MIRL, p18-20, protectin, surface anitgen recognized by monoclonal 16.3A5, T cell-activating protein
Gensymboler CD59
Värd art Mouse
Immunogen Recombinant full-length human CD59 protein (Uniprot: P13987)
Molekylvikt av antigen 20 kDa
Reningsmetod Protein L or PEG purified
Kvantitet 7 mL
Regulatorisk status RUO
Forskningsdisciplin Cell Biology, Cellular Markers, Immunology, Signal Transduction, Stem Cell Markers
Primär eller sekundär Primary
Gen-ID (Entrez) 966
Testspecificitet Reacts with human CD59, a 20kDa glycosyl phosphatidyl-inositol (GPI)-anchored cell surface protein. CD59 regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. CD59 is widely distributed on cells in all tissues. It inhibits formation of MAC, thus protecting cells from complement-mediated lysis. The expression of CD59 on erythrocytes is important for their survival. Genetic defects in GPI-anchor attachment, that cause a reduction or loss of CD59 and CD55 on erythrocytes produce the symptoms of the disease paroxysmal hemoglobinuria (PNH). It is useful for study on GPI-anchored proteins, PNH and CD59 functions.
Målarter Human, Baboon (Negative), Equine (Negative)
Innehåll och lagring Store at 4C.
Form Purified
Isotyp IgM κ
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