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CD6, PE, clone: IM348, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 12-0061-80

Additional Details : Weight : 0.25000kg

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Product Code. 15248439

  • 1106.00 SEK / 25µg


Estimated Shipment date
from Supplier 26-09-2018
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Description

Description

Description: The monoclonal antibody IM348 recognizes mouse CD6, a transmembrane glycoprotein of the scavenger receptor family. The extracellular domain contains three scavenger receptor cysteine rich (SRCR) domains, a transmembrane region and a cytoplasmic domain of variable length depending on the isoform. CD6 is expressed on most T lymphocytes. Expression between human and mouse is slightly different. In mice B cells in the spleen do not have CD6, while humans express it on a subset of B lymphocytes. The CD6 ligand is CD166, also known as Activated Leukocyte Cell Adhesion Molecule (ALCAM). Through interactions with CD166 or homotypic CD6-CD6, a role exists in adhesion and migration during organogenesis. The intracellular domain of CD6 is constitutively phosphorylated, suggesting a role in T cell activation and signaling. In humans depletion of CD6-expressing cells increases graft versus host tolerance in transplants.Applications Reported: This IM348 antibody has been reported for use in flow cytometric analysis.Applications Tested: This IM348 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

CD6
Monoclonal
0.2mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
Q61003
FLJ44171, TP120, CD6 antigen, T-cell differentiation antigen CD6, T12
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Murine
Flow Cytometry
IM348
PE
Cd6
Liquid
Cd6
IgG2a
25μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary
12511
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