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CD61 (Integrin beta 3) Mouse anti-Baboon, Canine, Cynomolgus Monkey, Human, Rhesus Monkey, Clone: VI-PL2, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-0619-80

Additional Details : Weight : 0.01000kg

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Product Code. 15237037

  • 646.00 SEK / 25µg

Estimated Shipment: 28-07-2021

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Description

Description

Description: The VI-PL2 monoclonal antibody reacts with human CD61, also known as integrin beta 3 and GPIIIa. CD61 is a 90-110 kDa member of the beta integrin family expressed by a wide variety of cells, including leukocytes, platelets, endothelial and smooth muscle cells. CD61 binds non-covalently with the alpha integrins CD41 and CD51, to form the alpha IIb beta3 (CD41/CD61) and alpha v beta3 (CD51/CD61) complexes. These alpha beta heterodimers are capable of mediating a variety of cellular responses including adhesion, trafficking, proliferaton and differentiation. The CD41/CD61 integrin has been shown to be involved in platelet aggregation, and binds to fibrinogen, von Willebrand Factor (vWF) and fibronectin. The CD51/CD61 integrin binds to matrix proteins including vitronectin, fibronectin, vWF and fibrinogen, and has been shown to have a strong role in modulating the migration and survival of angiogenic endothelial cells. This VI-PL2 antibody has also been shown to crossreact with canine and several non-human primate species, including baboon, rhesus, and cynomologus monkey. Applications Reported: This VI-PL2 antibody has been reported for use in flow cytometric analysis, immunoprecipitation, immunohistochemical staining, and functional assays. Applications Tested: This VI-PL2 antibody has been tested by flow cytometric analysis of human peripheral blood platelets. This can be used at less than or equal to 0.125 µg per test.

A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered. The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.
Specifications

Specifications

CD61 (Integrin beta 3)
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P05106
BDPLT2, CD61, GP3A, GPIIIa, GT, integrin beta-3, platelet glycoprotein IIIa, platelet membrane glycoprotein IIIa, ITGB3
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Baboon, Canine, Cynomolgus Monkey, Human, Rhesus Monkey
Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Western Blot
VI-PL2
Unconjugated
ITGB3
Liquid
ITGB3
IgG1, kappa
25 μg
4° C
Primary
102117791, 3690, 403788, 717379
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For Research Use Only.