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CD61 (Integrin beta 3) Mouse anti-Baboon, Canine, Cynomolgus Monkey, Human, Rhesus Monkey, FITC, Clone: VI-PL2, eBioscience™

Mouse Monoclonal Antibody

828.00 SEK - 1918.00 SEK

Specifications

Antigen CD61 (Integrin beta 3)
Clone VI-PL2
Target Species Baboon, Canine, Cynomolgus Monkey, Human, Rhesus Monkey
Conjugate FITC
Isotype IgG1, kappa
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15566426
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Affymetrix eBioscience
11-0619-41
25 Tests
828.00 SEK
25 tests
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Estimated Shipment
02-03-2021
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15576426
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Affymetrix eBioscience
11-0619-42
100 Tests
1918.00 SEK
100 tests
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In stock, ready to ship: 1
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Description

Description

Description: The VI-PL2 monoclonal antibody reacts with human CD61, also known as integrin beta 3 and GPIIIa. CD61 is a 90-110 kDa member of the beta integrin family expressed by a wide variety of cells, including leukocytes, platelets, endothelial and smooth muscle cells. CD61 binds non-covalently with the alpha integrins CD41 and CD51, to form the alpha IIb beta3 (CD41/CD61) and alpha v beta3 (CD51/CD61) complexes. These alpha beta heterodimers are capable of mediating a variety of cellular responses including adhesion, trafficking, proliferaton and differentiation. The CD41/CD61 integrin has been shown to be involved in platelet aggregation, and binds to fibrinogen, von Willebrand Factor (vWF) and fibronectin. The CD51/CD61 integrin binds to matrix proteins including vitronectin, fibronectin, vWF and fibrinogen, and has been shown to have a strong role in modulating the migration and survival of angiogenic endothelial cells. This VI-PL2 antibody has also been shown to crossreact with canine and several non-human primate species, including baboon, rhesus, and cynomologus monkey. Applications Reported: This VI-PL2 antibody has been reported for use in flow cytometric analysis. Applications Tested: This VI-PL2 antibody has been pre-titrated and tested by flow cytometric analysis of human platelets. This can be used at 5 µL (025 µg) per test.

A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser. Filtration: 0.2 μm post-manufacturing filtered. The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.
Specifications

Specifications

CD61 (Integrin beta 3)
Baboon, Canine, Cynomolgus Monkey, Human, Rhesus Monkey
IgG1, kappa
Monoclonal
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!
VI-PL2
FITC
Flow Cytometry
Primary
Monoclonal
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
RUO
SDS

For Research Use Only.