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CD86 Monoclonal Antibody (BU63), PerCP, Invitrogen™
Mouse Monoclonal Antibody
Brand: Invitrogen A15805
Additional Details : Weight : 0.00280kg
Description
CD86 is one of two ligands (the other CD80) for CTLA4 and CD28. CD86 acts as costimulatory molecule in eliciting T-cell help during antigen presentation. Antigen presentation in the absence of sufficient co-stimulation involving CD86/CD80 can induce tolerance. CD80 appears to play a role distinct from CD80 in T helper cell differentiation. CD86 is a type I membrane protein that is a member of the immunoglobulin superfamily. The CD86 protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of CD86 with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of CD86 with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in two transcript variants encoding different isoforms of CD86. Additional transcript variants have been described for CD86, but their full-length sequences have not been determined. Diseases associated with CD86 dysfunction include gallbladder squamous cell carcinoma and myocarditis.Specifications
CD86 | |
Monoclonal | |
PerCP | |
CD86 | |
B7-2, B7.2, B70, CD28LG2, LAB72, MGC34413, B-lymphocyte activation antigen B7-2, B-lymphocyte antigen B7-2, B7-2 antigen, BU63, CD28 antigen ligand 2 | |
Mouse | |
Purified | |
RUO | |
942 | |
4° C | |
Liquid |
Flow Cytometry | |
BU63 | |
PBS with 0.2% BSA and 15mM sodium azide | |
P42081 | |
CD86 | |
B-lymphoblastoid cell line ARH 77 | |
100 Tests | |
Primary | |
Human | |
Antibody | |
IgG1 |