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CDK14 (PFTK1)/cyclin Y Recombinant Human Protein

CDK14 (PFTK1)/cyclin Y Recombinant Human Protein

Brand:  Invitrogen PV6382

UNSPSC : 12352202

Additional Details : Weight : 0.01000kg

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Product Code. 15459013

  • 2975.00 SEK / 10µg


Estimated Shipment date
from Supplier 04-09-2017
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Disclaimers:

For Research Use Only. Not for use in diagnostic procedures.


Description

Description

CDK14 (PFTK1)/cyclin Y is a member of the CDC2-related protein kinase family which is expressed primarily in the postnatal and adult nervous system. CDK14 is expressed at high levels in brain, pancreas, kidney, heart, testis, and ovary. CDK14 amino acid residue ser119 is required for its interaction with all four 14-3-3 isoforms, while ser120 may contribute slightly to CDK14 binding. CDK14 acts as a cyclin-dependent kinase that regulates cell cycle progression and cell proliferation. Overexpression of CDK14 predicts resistance to chemotherapy in patients with oesophageal squamous cell carcinoma. Recombinant human full-length CDK14 and Cyclin Y (2-end) were co-expressed by baculovirus in Sf9 insect cells using N-terminal GST tags.

  • Validated in LanthaScreen™ Kinase Binding Assay
  • Protocols available for simple use and optimized performance
  • Multiple pack sizes available for convenient use

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  • Specifications

    Specifications

    NP_036527.1, NP_659449.3
    Pharma and biopharma, protein assays and analysis, target and lead identification and validation
    CDK14 (PFTK1)/Cyclin Y Recombinant Human Protein
    >90% by SDS-PAGE
    –68 to –85°C
    1 Each
    CDK14 (PFTK1)/Cyclin Y Recombinant Human Protein
    Kinase assay
    CDK14 (PFTK1)/Cyclin Y Recombinant Human Protein
    Human
    0.1mg/mL
    77/65.5kDa
    7.5
    10μg
    For research use only. Not for use in diagnostic procedures
    PFTK1: CDK14; PFTAIRE1, cyclin Y: CCNY; C10orf9; CBCP1; CCNX; CFP1
    CDK14 (PFTK1)/cyclin Y was pre-diluted in enzyme dilution buffer and assayed in 5mM MOPS (pH 7.2), 2.5mM β-glycerol-phosphate, 5mM MgCl2, 0.4mM EDTA, 1mM EGTA, 0.05mM DTT, with 50μM ATP, trace [33P]-γ-ATP and 200μg/mL myelin basic protein (MBP) for 15 min.s at 30°C
    Amino acids Full, 2-end
    2.5nmoles of phosphate transferred to myelin basic protein (MBP) per minute per mg of total protein at 30°C
    GST Tag