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Eurofins DiscoverX Cdk3/Cyclin E Protein, Active
Beskrivning
The cyclin-dependent kinases (CDKs), a subfamily of protein kinases, promote cell cycle progression. In mammals, nine different CDKs (cdk 1 to cdk 9; cdk 1 is better known as cdc 2) have been identified. CDKs are regulated on various levels including binding of proteins (cyclins, inhibitors, and assembly factors), protein degradation, transcriptional control, localization, and multiple phosphorylations. This leads to timely regulation of CDK activity, allowing progression from one cell cycle phase to the next. Cdk3 participates in the G1–S progression at least partially by binding to E2F-1, E2F-2, or E2F-3 through DP-1 and by enhancing their transcriptional activities.
GenBank X66357 / GenBank NM_001238
Specifikationer
Specifikationer
| Formulering | mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 150 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. |
| Molekylvikt (g/mol) | 36 kDa (CDK3) and 74 kDa (Cyclin E) |
| Kvantitet | 10 μg |
| Art | Human |
| Rekombinant | Recombinant |
| Protein Tag | C-terminal 6His / N-terminal GST |
| Uttryckssystem | Recombinant enzyme expressed in Sf21 insect cells |
| Proteinform | Full-length |
| Renhet eller kvalitetsklass | ≥58% |
| Protein | CDK3/Cyclin E, active |
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