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Invitrogen™ Human CDK7/Cyclin H/MNAT1, His Tag Recombinant Protein

Produktkod. 15474603
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Kvantitet:
10 μg
100 μg
Förpackningsstorlek:
100µg
10µg
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Produktkod. 15474603

Brand: Invitrogen™ PR6749B

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Beskrivning

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Recombinant, Full Length.

The trimeric complex of CDK7, cyclin H and MNAT1, functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This complex is thought to serve as a direct link between the regulation of transcription and the cell cycle. The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). CDK7 may be a target of germline cancer-inducing mutations.
TRUSTED_SUSTAINABILITY

Specifikationer

Tillträdesnummer P50613
Koncentration See Label
För användning med (applikation) Kinase Assay
Formulering 50mM tris with 150mM NaCl, 0.5mM EDTA, 2mM DTT, 50% glycerol, 0.02% Triton X-100 and no preservative; pH 7.5
Gen-ID (Entrez) 1022
Molekylvikt (g/mol) 43.2-42.6-40.5 kDa
Namn Human CDK7/Cyclin H/MNAT1, His Tag
pH-intervall 7.5
Reningsmetod Purified
Kvantitet 100 μg
Förvaringskrav -80°C, Avoid Freeze/Thaw Cycles
Regulatorisk status RUO
Gene Alias 39 KDa protein kinase; 39 protein kinase; AI323415; AI528512; C230069N13; CAK; CAK1; CDK; CDK7; CDK-activating kinase; CDK-activating kinase 1; Cdkn7; cell division protein kinase 7; CR4 protein kinase; CRK4; CRK4 PK (CDC2-related-kinase-4 protein kinase); cyclin dependent kinase 7; cyclin-dependent kinase 7; cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase); cyclin-dependent kinase 7 (MO15 homolog Xenopus laevis cdk-activating kinase); cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase); EC 2.7.11.22; EC 2.7.11.23; HCAK; homolog of Xenopus MO15 Cdk-activating kinase; kinase subunit of CAK; MO15; Mpk-7; OTTHUMP00000222032; OTTHUMP00000222033; p39 Mo15; p39MO15; Protein-tyrosine kinase MPK-7; serine/threonine kinase stk1; serine/threonine protein kinase 1; serine/threonine protein kinase MO15; Serine/threonine-protein kinase 1; STK1; TFIIH basal transcription factor complex kinase subunit
Vanligt namn CDK7
Gensymbol CDK7
KinaseFamily CDK and CHK Kinase Family
Produkttyp Protein
Konjugera Unconjugated
Art Human
Rekombinant Recombinant
Protein Tag His-tag
Sekvens Full length
Innehåll och lagring -80°C, Avoid Freeze/Thaw Cycles
Kinase Group Ser⁄Thr Kinases: CMCG Group
Frakt skick Dry Ice
Uttryckssystem Insect cells
Proteinfamilj Kinases & Inhibitors
Proteinform Recombinant, Full Length
Form Liquid
Forskningskategori Cell Cycle & Proliferation, Signal Transduction
Renhet eller kvalitetsklass 70% by SDS-PAGE
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