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CLCN1 Rabbit anti-Human, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 18595-1-AP-150UL
Additional Details : Weight : 0.00010kg
Description
The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport and maintain cellular volume. CLC1 is highly expressed in skeletal muscle. Mutations in the gene encoding CLC1 lead to myotonia, an inheritable disorder characterized by muscle stiffness and renal salt wasting. CLC2 is highly expressed in the epithelia of several organs including lung, which suggests CLC2 may be a possible therapeutic target for cystic fibrosis. CLC3 expression is particularly abundant in neuronal tissue, while CLC4 expression is evident in skeletal and cardiac muscle as well as brain. Mutations in the gene encoding CLC5 lead to Dents disease, a renal disorder characterized by proteinuria and hypercalciuria. CLC6 and CLC7 are broadly expressed in several tissues including testis, kidney, brain and muscle.Specifications
CLCN1 | |
Polyclonal | |
Unconjugated | |
CLCN1 | |
Chloride channel protein 1, ClC 1, CLC1, CLCN1 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
1180 | |
-20°C | |
Liquid |
ELISA | |
0.15 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
P35523 | |
CLCN1 | |
CLCN1 Fusion Protein Ag13336 | |
150 μL | |
Primary | |
Human | |
Antibody | |
IgG |