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Invitrogen™ CSK Monoclonal Antibody (C.678.4)
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Produktkod. 11574881
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Kvantitet:
100 μL
Förpackningsstorlek:
100µL
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Produktkod. Kvantitet unitSize
11574881 100 μL 100µL
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Produktkod. 11574881 Leverantör Invitrogen™ Leverantörsnummer MA514915

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Beskrivning

Rabbit Monoclonal Antibody

It is not recommended to aliquot this antibody. This antibody is not cross-reactive with other proteins.

CSK is a tyrosine kinase that has been shown to downregulate the activity of SRC oncoprotein through phosphorylation of its carboxy terminus. Since cell transformation by SRC is caused by various mechanisms that interfere with this phosphorylation, the CSK gene might function as an antioncogene. CSK plays an important role in the regulation of cell growth, differentiation, migration, and immune responses. CSK phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases including LCK, SRC, HCK, FYN, LYN, CSK, and YES1. CSK is expressed ubiquitously as a protein of approximately 50 KDa in cytosol, but a fraction distributes to lipid rafts due to interaction with the lipid raft-associated protein PAG (Csk-binding protein).
TRUSTED_SUSTAINABILITY

Specifikationer

Antigen CSK
Användningsområden Western Blot
Klassificering Monoclonal
Klona C.678.4
Koncentration 29 μg/mL
Konjugera Unconjugated
Formulering 0.01M HEPES with 100μg/mL BSA, 0.15M NaCl, 50% glycerol and <0.02% sodium azide; pH 7.5
Gen CSK
Genaccessionsnr. P32577, P41240, P41241
Gene Alias AW212630; CSK; CSK, non-receptor tyrosine kinase; C-SRC kinase; c-src tyrosine kinase; C-terminal Src kinase; MGC117393; p50CSK; protein-tyrosine kinase (CSK); protein-tyrosine kinase CYL; Protein-tyrosine kinase MPK-2; Tyrosine-protein kinase CSK
Gensymboler CSK
Värd art Rabbit
Immunogen Synthetic peptide corresponding to residues surrounding amino acid residue Val399 of human Csk.
Reningsmetod Affinity chromatography
Kvantitet 100 μL
Regulatorisk status RUO
Primär eller sekundär Primary
Gen-ID (Entrez) 100154110, 12988, 1445, 315707
Målarter Human, Mouse, Rat, Monkey, Pig
Innehåll och lagring -20°C
Produkttyp Antibody
Form Liquid
Isotyp IgG
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Produkttitel
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