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CTDSP1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 10952-1-AP-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16827683

  • 1236.20 SEK / 20µL
Estimated Shipment: 07-12-2021

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Description

Description

CTDSP1 is a class 2C phosphatase with activity dependent on the conserved DxD motif. Expression of CTDSP1 inhibited activated transcription from several promoter-reporter gene constructs, but expression of a mutant lacking phosphatase activity enhanced transcription. Neuronal gene transcription is repressed in nonneuronal cells by the repressor element-1 (RE1)-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF; 600571) complex. REST/NRSF recruits SCPs to neuronal genes that contain RE1 elements, leading to neuronal gene silencing in nonneuronal cells. Phosphatase-inactive forms of SCP interfere with REST/NRSF function and promote neuronal differentiation of P19 stem cells. Likewise, small interfering RNA directed to the single Drosophila SCP unmasks neuronal gene expression in S2 cells. Thus, SCP activity is an evolutionarily conserved transcriptional regulator that acts globally to silence neuronal genes.
Specifications

Specifications

CTDSP1
0.3 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P58466, Q9GZU7
CTDSP1, NIF3, NLI IF, NLI interacting factor 3, NLIIF, SCP1, Small CTD phosphatase 1
Rabbit
IgG
20 μL
-20°C
Primary
227292, 363249, 58190
Western Blot
Unconjugated
CTDSP1
Liquid
Ctdsp1
CTDSP1 Fusion Protein Ag1410
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Rat, Mouse, Human
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