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Invitrogen™ Cullin 2 Polyclonal Antibody

Beskrivning
Cullin 2 Polyclonal Antibody for ELISA, IHC (P), IP, Western Blot
Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). [UniProt].
Specifikationer
Specifikationer
| Antigen | Cullin 2 |
| Användningsområden | ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot |
| Klassificering | Polyclonal |
| Koncentration | 0.25 mg/mL |
| Konjugera | Unconjugated |
| Formulering | PBS with 0.1% sodium azide; pH 7.4 |
| Gen | Cul2 |
| Genaccessionsnr. | Q13617, Q9D4H8 |
| Gene Alias | 1300003D18Rik; 4932411N15Rik; AI327301; CUL2; CUL-2; cullin 2; cullin-2; MGC131970; mKIAA4106; OTTHUMP00000019437; testis secretory sperm-binding protein Li 238E |
| Gensymboler | Cul2 |
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Produkttitel
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