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Invitrogen™ Cyclin B1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA5122055
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Beskrivning
Cyclin B1 Polyclonal Antibody for Western Blot
Cyclins bind to and regulate the activity of the Cyclin dependent protein kinases (CDKs). Cyclin B1 or CCNB1 is a regulatory protein involved in mitosis. It is essential for the control of the cell cycle at the G2/M transition. Cyclin B1 complexes with p34 (cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. Cyclin B1 is not ubiquitinated during G2/M phase, resulting in its steady accumulation during G2 phase, followed by abrupt APC dependent destruction at the end of mitosis. Destruction of Cyclin B1 is required for cell cycle progression. Cyclin B1 is overexpressed in various cancers, including breast, prostate, and non-small cell lung cancer.
Specifikationer
| Cyclin B1 | |
| Polyclonal | |
| Unconjugated | |
| Ccnb1 | |
| Ccn-2; CCNB; Ccnb1; Ccnb1-rs1; Ccnb1-rs13; Cycb; Cycb1; Cycb1-rs1; Cycb-4; Cycb-5; cyclin B; cyclin B1; cyclin B1, related sequence 1; cyclin B1, related sequence 13; G2/mitotic-specific cyclin B1; G2/mitotic-specific cyclin-B1; I79_013589; OTTHUMP00000221981; OTTHUMP00000223023 | |
| Rabbit | |
| Antigen affinity chromatography, Protein A | |
| RUO | |
| 891 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Western Blot | |
| 0.5 mg/mL | |
| PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4 | |
| P14635 | |
| Ccnb1 | |
| Recombinant protein Cyclin B. The antigen corresponds to amino acid range 239-433 of the target protein. | |
| 20 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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