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Cyclophilin A Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 10720-1-AP-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16877283

  • 1211.96 SEK / 20µL
Estimated Shipment: 30-11-2021

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Description

Description

Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs) and those that bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase′s, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins. Within the cyclophilin family, there are several different proteins which show a high degree of homology including CyPA, CyPB and CyPC. CyPA, also termed CyP-18, is the most abundant and ubiquitous cyclophilin found in all vertebrate tissues and is present in T-cells.
Specifications

Specifications

Cyclophilin A
0.32 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P10111, P17742, P62937
Cyclophilin A, Cyclosporin A binding protein, CYPA, CYPH, PPIA, PPIase A, Rotamase A
Rabbit
IgG
20 μL
-20°C
Primary
25518, 268373, 5478
Immunohistochemistry (Paraffin), Immunocytochemistry, Western Blot, Immunofluorescence, Flow Cytometry
Unconjugated
PPIA
Liquid
PPIA
Cyclophilin A Fusion Protein Ag1120
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Mouse, Human, Rat
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