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DAAM1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 14876-1-AP-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16883754

  • 1211.96 SEK / 20µL
Estimated Shipment: 30-11-2021

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Description

Description

This antibody well recognizes the endogenous DAAM1 protein around 120 kDa.

DAAM1 is a diaphanous-related formin first studied as a novel Disheveled binding protein and shown to be crucial for the planar cell polarity pathway in Xenopus. DAAM1, like other formins, directs nucleation and elongation of new actin filaments using its conserved formin-homology-2 (FH2) domain. It is a Rho-regulated formin implicated in neuronal development and regulation of gastrulation. It was identified as a binding protein of the Wnt receptor-associated protein Disheveled. It also binds the GTP-bound RhoA and increases its GTP-bound form population in cells. It exists in an autoinhibited state via intramolecular interactions between its amino-terminal GBD and carboxyl-terminal DAD domains. Structurally the protein includes a GTPase-binding domain (GBD), a diaphanous inhibitory domain (DID), and a coiled-coil region followed by the FH1, FH2 and C-terminal diaphanous auto-regulatory domain (DAD). In humans, the DAAM1 gene is mapped to chromosome 14q23.1.
Specifications

Specifications

DAAM1
0.21 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q8BPM0, Q9Y4D1
DAAM1, KIAA0666
Rabbit
IgG
20 μL
-20°C
Primary
208846, 23002, 314212
Western Blot, Immunofluorescence, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation
Unconjugated
DAAM1
Liquid
Daam1
DAAM1 Fusion Protein Ag6648
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Mouse, Human, Rat
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