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DAAM1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

1656.73 SEK - 4721.67 SEK

Specifications

Antigen DAAM1
Concentration 0.21 mg/mL
Applications Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Polyclonal
Conjugate Unconjugated
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
16883754
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Proteintech
14876-1-AP-20UL
20 μL
1656.73 SEK
20µL
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Estimated Shipment: 02-04-2024
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16873754
View Documents Promotion Details
Proteintech
14876-1-AP-150UL
150 μL
4721.67 SEK
150µL
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Estimated Shipment: 02-04-2024
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Description

Description

This antibody well recognizes the endogenous DAAM1 protein around 120 kDa.

DAAM1 is a diaphanous-related formin first studied as a novel Disheveled binding protein and shown to be crucial for the planar cell polarity pathway in Xenopus. DAAM1, like other formins, directs nucleation and elongation of new actin filaments using its conserved formin-homology-2 (FH2) domain. It is a Rho-regulated formin implicated in neuronal development and regulation of gastrulation. It was identified as a binding protein of the Wnt receptor-associated protein Disheveled. It also binds the GTP-bound RhoA and increases its GTP-bound form population in cells. It exists in an autoinhibited state via intramolecular interactions between its amino-terminal GBD and carboxyl-terminal DAD domains. Structurally the protein includes a GTPase-binding domain (GBD), a diaphanous inhibitory domain (DID), and a coiled-coil region followed by the FH1, FH2 and C-terminal diaphanous auto-regulatory domain (DAD). In humans, the DAAM1 gene is mapped to chromosome 14q23.1.
Specifications

Specifications

DAAM1
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Unconjugated
Rabbit
Human, Mouse, Rat
Q8BPM0, Q9Y4D1
208846, 23002, 314212
DAAM1 Fusion Protein Ag6648
Primary
-20°C
DAAM1
0.21 mg/mL
Polyclonal
Liquid
RUO
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
DAAM1, KIAA0666
Daam1
IgG
Antigen Affinity Chromatography
Antibody
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SDS
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Documents

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