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STEMCELL Technologies Dasatinib

Produktkod. 17120172
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17120172 100 mg
17110172 10 mg
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Produktkod. 17120172 Leverantör STEMCELL Technologies Leverantörsnummer 73084

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Beskrivning

Tyrosine kinase inhibitor; Inhibits ABL, SRC, LCK, and YES

  • Dasatinib is a potent, ATP-competitive tyrosine kinase inhibitor
  • It is specific for SRC/ABL kinases, for example, ABL, SRC, LCK, and YES with IC50 values of < 1.0, 0.5, 0.4 and 0.5 nM, respectively, and also demonstrates activity against KIT with an IC50 = 5.0 nM (Lombardo et al.; Davis et al.) Dasatinib is a second-generation inhibitor of the oncogenic tyrosine kinase BCR-ABL with 325-fold more potency than imatinib, and is also able to inhibit imatinib-resistant BCR-ABL mutants (Tokarski et al.) It also inhibits a large number of other kinases (76 of 148 kinases tested) when screened at 10 μM (Carter et al.)

Specifikationer

CAS 302962-49-8
Synonym BMS 354825; Sprycel
Kvantitet 100 mg
Molekylformel C22H26ClN7O2S
Renhet ≥98%
Produkttitel
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