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DICER1 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 20567-1-AP-150UL

Additional Details : Weight : 0.00010kg

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Product Code. 16840125

  • 3313.85 SEK / 150µL
Estimated Shipment: 03-10-2022
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Description

Description

The antibody is specific to DICER1. The calculated molecular weight of DICER1 is 219 kDa, but modified DICER1 is about 220-250 kDa. DICER1 has isoforms with molecular weight 219 kDa and 93 kDa.

Sphingosine Kinase (SphK) catalyzes the phosphorylation of the lipid sphingosine, creating the bioactive lipid sphingosine-1-phosphate (S1P). S1P subsequently signals through cell surface G protein-coupled receptors, as well as intracellularly, to modulate cell proliferation, survival, motility and differentiation. SphK is an important signaling enzyme which is activated by diverse agents, including growth factors that signal through receptor tyrosine kinases, agents activating G protein-coupled receptors, and immunoglobulin receptors. Two SphK isotypes, SphK-1 and SphK-2, have been cloned, and both isotypes are ubiquitously expressed. SphK-1 has been shown to mediate cell growth, prevention of apoptosis, and cellular transformation, and is upregulated in a variety of human tumors. In contrast, SphK-2 increases apoptosis, and may be responsible for phosphorylating and activating the immunosuppressive drug FTY720.
Specifications

Specifications

DICER1
Polyclonal
Unconjugated
DICER1
DCR1, Dicer, dicer 1, ribonuclease type III, DICER1, Endoribonuclease Dicer, Helicase MOI, Helicase with RNase motif, HERNA, KIAA0928
Rabbit
Antigen Affinity Chromatography
RUO
23405
-20°C
Liquid
Western Blot, Immunoprecipitation, Immunohistochemistry (Paraffin), Immunofluorescence, Immunocytochemistry
0.57 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q9UPY3
DICER1
Peptide
150 μL
Primary
Human
Antibody
IgG
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