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Tocris Bioscience™ DMH-1
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Produktkod. 18065942
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18065942 50 mg
18005362 10 mg
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Produktkod. 18065942 Leverantör Tocris Bioscience™ Leverantörsnummer 4126/50

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Beskrivning

Selective ALK2 inhibitor

DMH-1 is a selective inhibitor of bone morphogenic protein (BMP) type-I receptor activin receptor-like kinase 2 (ALK2) receptor (IC50 = 108 nM or 12.6 nM in in vitro kinase assays). DMH-1 exhibits 6- and 19-fold selectivity for ALK-2 over ALK-1 and ALK-3, respectively, and no significant inhibition of AMPK, ALK5, KDR (VEGFR-2) or PDGFRβ receptors. DMH-1 blocks BMP4-induced phosphorylation of Smads 1, 5 and 8 in HEK293 cells. Promotes neurogenesis in human induced pluripotent stem cells (iPSCs) when used in combination with SB 431542 (Cat. No. 1614). DMH-1 suppresses lung cancer cell proliferation, migration, invasion in vitro and reduces tumor growth in a mouse lung cancer xenograft model. DMH-1 inhibits cellular autophagy responses. DMH-1 induces intestinal differentiation in human intestinal organoids (hIOs) derived from human pluripotent stems cells (hPSCs).
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Kemiska identifierare

CAS 1206711-16-1
Molekylformel C24H20N4O

Specifikationer

Kemiskt namn eller material DMH-1
Kvantitet 50 mg
Formel vikt 380.44
Renhet >98%
Molekylvikt (g/mol) 380.45
Produkttitel
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