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Eurofins DiscoverX DNA-PK Protein, Active

Produktkod. 17300844
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Kvantitet:
10 μg
250 μg
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Produktkod. Kvantitet
17300844 10 μg
17310844 250 μg
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Produktkod. 17300844 Leverantör Eurofins DiscoverX Leverantörsnummer 14950

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Beskrivning

Active, Recombinant, human FLAG-tagged DNA-PK (GenBank NM_006904.6) full length, for use in Kinase Assays

Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). Recruited by XRCC5 and XRCC6 to DNA ends and is required to protect and align broken ends of DNA, thereby preventing their degradation, and sequester the DSB for repair by NHEJ. Act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription. As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome.

GenBank NM_006904.6

Specifikationer

Formulering mg/mL of enzyme in storage buffer.
Molekylvikt (g/mol) 470 kDa
Kvantitet 10 μg
Art Human
Rekombinant Recombinant
Protein Tag FLAG-tag
Uttryckssystem Recombinant enzyme expressed in mammalian cells
Proteinform Full-length
Renhet eller kvalitetsklass ≥39%
Protein DNA-PK, active
Produkttitel
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