Invitrogen™ DNAI1 Polyclonal Antibody

Beskrivning

Immunogen sequence: VGYGSYDFMK QSRGMLLLYS LKNPSFPEYM FSSNSGVMCL DIHVDHPYLV AVGHYDGNVA IYNLKKPHSQ PSFCSSAKSG KHSDPVWQVK WQKDDMDQNL NFFSVSSDGR IVSWTLVKRK LVHIDVIKLK VEGSTTEVPE GLQLHPVGCG TAFDFHKEID YMFLVGTEEG KIYKCSKSYS SQFLDTYDAH NMSVDTVSWN PYHTKVFMSC SSDWTVKIWD HTIKTPMFIY DLNSAVGDVA WAPYSSTVFA AVTTDGKAHI FDLAINKYEA ICNQPVAAKK NRLTHVQFNL IHPIIIVGDD RGHIISLKLS PNLRKMPKEK KGQEVQKGPA VEIAKLDKLL NLVREVKIKT; Positive Samples: HeLa, SKOV3, U-87MG, Mouse kidney; Cellular Location: Cytoplasm, cilium axoneme, cytoskeleton.

Eukaryotic cells rely on actin and microtubule-based protein motors to generate intracellular movements. These protein motors contain specialized domains that hydrolyze ATP to produce force and movement along a cytoskeletal polymer (actin in the case of myosin family and microtubules in the case of the kinesin family and dyneins). Dynein has been implicated in cytoplasmic motile functions, including chromosomal movement, retrograde organelle and axonal transport, the endocytic pathway, and the organization of the Golgi apparatus. In all cell types, dynein has the same basic structures and is composed of two or three distinct heavy chains (~450 kDa), three intermediate chains (70-125 kDa), and at least four light chains (15-25 kDa).