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DUT Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 13740-1-AP-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16822114

  • 1236.20 SEK / 20µL
Estimated Shipment: 07-12-2021

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Description

Description

This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.
Specifications

Specifications

DUT
0.39 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P33316, P70583
deoxyuridine triphosphatase, DUT, dUTP pyrophosphatase, dUTPase
Rabbit
IgG
20 μL
-20°C
Primary
110074, 1854, 497778
Immunohistochemistry (Paraffin), Immunofluorescence, Immunocytochemistry, Immunoprecipitation, Western Blot
Unconjugated
DUT
Liquid
DUT
DUT Fusion Protein Ag4677
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Mouse, Rat, Human
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