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EBI3 Mouse anti-Human, Porcine, Rat, Clone: 1F3H10, Proteintech

Mouse Monoclonal Antibody

Brand:  Proteintech 66354-1-IG-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16828155

  • 1236.20 SEK / 20µL
Estimated Shipment: 02-12-2021

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Description

Description

EBI3 is a subunit in two distinct heterodimeric cytokines: interleukin-27 (IL-27) and IL-35 (1-3). Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naive but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 (also known as TCCR) and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-gamma, and T-bet. IL-35 is composed of EBI3 and the p35 subunit of IL-12 and has been reported to have therapeutic effects against collagen-induced arthritis by expanding the population of regulatory T cells and suppressing Th17 cells. At least two isoform of EBI3 are known to exist.
Specifications

Specifications

EBI3
1F3H10
Unconjugated
EBI3
Liquid
EBI3
EBI3 Fusion Protein Ag3051
Protein G
RUO
Antibody
Monoclonal
Rat, Human, Porcine
Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q14213
EBI3, EBV induced gene 3 protein, Epstein Barr virus induced 3, IL 27 subunit beta, IL 27B, IL27B, Interleukin 27 subunit beta
Mouse
IgG1
20 μL
-20°C
Primary
100522599, 10148, 680609
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