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EBI3 Mouse anti-Human, Porcine, Rat, Clone: 1F3H10, Proteintech

Mouse Monoclonal Antibody

1656.73 SEK - 4721.67 SEK

Specifications

Antigen EBI3
Clone 1F3H10
Concentration 1 mg/mL
Applications Western Blot
Classification Monoclonal
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
16828155
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Proteintech
66354-1-IG-20UL
20 μL
1656.73 SEK
20µL
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Estimated Shipment: 03-04-2024
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16818155
View Documents Promotion Details
Proteintech
66354-1-IG-150UL
150 μL
4721.67 SEK
150µL
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Estimated Shipment: 03-04-2024
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Description

Description

EBI3 is a subunit in two distinct heterodimeric cytokines: interleukin-27 (IL-27) and IL-35 (1-3). Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naive but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 (also known as TCCR) and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-gamma, and T-bet. IL-35 is composed of EBI3 and the p35 subunit of IL-12 and has been reported to have therapeutic effects against collagen-induced arthritis by expanding the population of regulatory T cells and suppressing Th17 cells. At least two isoform of EBI3 are known to exist.
Specifications

Specifications

EBI3
1 mg/mL
Monoclonal
Liquid
RUO
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
EBI3, EBV induced gene 3 protein, Epstein Barr virus induced 3, IL 27 subunit beta, IL 27B, IL27B, Interleukin 27 subunit beta
EBI3
IgG1
Protein G
Antibody
1F3H10
Western Blot
Unconjugated
Mouse
Rat, Human, Porcine
Q14213
100522599, 10148, 680609
EBI3 Fusion Protein Ag3051
Primary
-20°C
EBI3
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SDS
Documents

Documents

Product Certifications