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Tocris Bioscience™ EED 226
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Produktkod. 18727786
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Produktkod. Kvantitet
18727786 10 mg
18719266 50 mg
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Produktkod. 18727786 Leverantör Tocris Bioscience™ Leverantörsnummer 7762/10

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Description

Potent and selective EED inhibitor

EED 226 is a potent (IC50 = 23.4 nM) and selective EED inhibitor. It inhibits PRC2 activity by binding to the H3K27me3 pocket of EED. The compound shows selectivity for PRC2 complex over protein methyltransferases, kinases, and other protein classes. In vitro, EED 226 regulates histone H3K27 methylation and PRC2 target gene expression. In vivo, it induces tumor regression in a mouse xenograft model. EED 226 is orally bioavailable.
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Specifications

Kemiskt namn eller material N-(2-Furanylmethyl)-8-[4-(methylsulfonyl)phenyl]-1,2,4-triazolo[4,3-c]pyrimidin-5-amine
CAS 2083627-02-3
Kvantitet 10 mg
Mål EED
Molekylformel C17H15N5O3S
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