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EGFR (ErbB1) [L861Q] Recombinant Human Protein

EGFR (ErbB1) [L861Q] Recombinant Human Protein

Brand:  Invitrogen PV3873

Additional Details : Weight : 0.05250kg

Product Code. 11503607

  • 5380.00 SEK / 10µg
Estimated Shipment: 16-04-2024
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For Research Use Only. All usage must comply with product instructions.


Description

Description

The epidermal growth factor receptor is a receptor tyrosine kinase that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The EGFR L861Q mutation is an Iressa-responsive mutant observed in the clinic.
Specifications

Specifications

NP_005219.2; L861Q
Pharma and Biopharma, Protein Assays and Analysis, Target and Lead Identification and Validation, Kinase Assay
90.5kDa
10μg
For research use only. Not for use in diagnostic procedures
EGFR (ErbB1) L861Q
EGFR (ErbB1) L861Q was pre-diluted in enzyme dilution buffer and assayed in 25mM Tris (pH 7.5), 10mM MgCl2, 0.5mM EGTA, 0.5mM Na3VO4, 5mM β-glycerophosphate, 2.5mM DTT, 0.01% Triton™ X-100, 200μM ATP, 200μg/mL Abl1 peptide substrate (EAIYAAPFAKKK) and trace [32P]-γ-ATP for 10 minutes at 30°C
Amino acids 668-1210: L858R, Amino acids 668-1210; L861Q
231nmoles of phosphate transferred to Abl1 peptide substrate (EAIYAAPFAKKK) per minute per mg of total protein at 30°C. Activity determined at a final protein concentration of 3.33μg/mL
GST Tag
Kinase and inhibitors
65% by SDS-PAGE
0.33mg/mL
114294, 1956
EGFR (ErbB1) [L861Q] Recombinant Human Protein
–80°C
1 Each
EGFR (ErbB1) [L861Q] Recombinant Human Protein
EGF receptor (ErbB)
EGFR (ErbB1) [L861Q] Recombinant Human Protein
Human
Baculovirus
Receptor tyrosine kinases
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For Research Use Only. Not for use in diagnostic procedures.