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EGFR (ErbB1) [T790M] [L858R] Recombinant Human Protein

EGFR (ErbB1) [T790M] [L858R] Recombinant Human Protein

Brand:  Invitrogen PR8911A

Additional Details : Weight : 0.01000kg

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Product Code. 15448693

  • 12870.00 SEK / 100µg


Estimated Shipment date
from Supplier 03-01-2018
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Disclaimers:

For Research Use Only. Not for use in diagnostic procedures.


Description

Description

The epidermal growth factor receptor is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The double T790M L858R mutant of EGFR displays resistance to Erlotinib (Tarceva) and sensitivity to HKI-272 and rapamycin combination therapy.
Specifications

Specifications

NP_005219.2; T790M L858R
Protein assays and analysis
Frozen
EGFR (ErbB1) [T790M] [L858R] Recombinant Human Protein
100μg
For research use only. Not for use in diagnostic procedures
EGFR (ErbB1) T790M L858R
EGFR T790M L858R was pre-diluted in enzyme dilution buffer and assayed in 20mM Tris (pH 7.5), 10mM MgCl2, 1mM EGTA, 1mM Na3VO4, 5mM β-glycerophosphate, 2mM DTT, 0.02% Triton™ X-100, 200μM ATP, 200μg/mL Abl1 peptide substrate (EAIYAAPFAKKK) and trace [32P]-γ-ATP for 10 minutes at 30°C
Baculovirus
Amino acids 668-1210
150nmoles of phosphate transferred to Abl1 peptide substrate (EAIYAAPFAKKK) per minute per mg of total protein at 30°C. Activity determined at a final protein concentration of 0.833μg/mL
GST Tag
0.38mg/mL
Frozen
90.6kDa
65% by SDS-PAGE
–80°C
1 Each
EGFR (ErbB1) [T790M] [L858R] Recombinant Human Protein
Kinase assay
EGF receptor (ErbB)
EGFR (ErbB1) [T790M] [L858R] Recombinant Human Protein
Human
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