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EIF2AK2 Mouse anti-Human, Clone: 2A8A4, Proteintech

Mouse Monoclonal Antibody

Brand:  Proteintech 66646-1-IG-150UL

Additional Details : Weight : 0.00010kg

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Product Code. 16878715

  • 3248.87 SEK / 150µL
Estimated Shipment: 30-11-2021

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Description

Description

This antibody is specific to EIF2AK2.

PKR is a 68 kDa protein and an IFN-induced serine/threonine protein kinase consisting of two N-terminal RNA-binding regulatory domains and a functional C-terminal serine/threonine protein kinase domain. Activated by dsRNA produced during viral infections, PKR plays a key role in IFN induced-innate antiviral response, virus-induced apoptosis, cell growth & differentiation. Upon activation, PKR gets autophosphorylated and catalyzes the phosphorylation of elF2 alpha subunit, which leads to an inhibition of protein synthesis. PKR induces apoptosis by up-regulating Fas expression and mediates FADD/Caspase-8 death signaling pathway. Upon viral infection, it functions as a dual protein, sequentially activating both cell survival & cell death pathways using kinase independent and dependent strategies. PRKR regulates multiple pathways which include NF-kappaB activation, p53, p38, & PDGF signaling pathway. PKR has been implicated in tumor suppression & maligcy. To evade the antiviral effects of PKR, viruses have evolved multiple mechanisms, such as the inhibition of PKR by the non-structural protein (NS1) of the influenza virus. More recently, PKR has been implicated in several neurodegenerative diseases including Alzheimer, Huntington, and amyotrophic lateral sclerosis.
Specifications

Specifications

EIF2AK2
2A8A4
Unconjugated
EIF2AK2
Liquid
EIF2AK2
EIF2AK2 Fusion Protein Ag13010
Protein G
RUO
Antibody
Monoclonal
Human
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P19525
eIF 2A protein kinase 2, EIF2AK1, EIF2AK2, P1/eIF 2A protein kinase, p68 kinase, PKR, PRKR, Protein kinase RNA activated
Mouse
IgG1
150 μL
-20°C
Primary
5610
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