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Invitrogen™ Human EIF2AK2 (PKR), GST Tag Recombinant Protein

Produktkod. 10022913
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Kvantitet:
10 μg
Förpackningsstorlek:
Varje
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For Research Use Only. All usage must comply with product instructions.

Produktkod. 10022913

Brand: Invitrogen™ PV4821

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Denna artikel kan inte returneras. Se returpolicy

For Research Use Only. All usage must comply with product instructions.

Beskrivning

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Catalytic.

EIF2AK2 (PKR) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses. EIF2AK2 plays a key role in antiviral defense mediated through its direct activation by double-stranded RNA produced by viral infection. PKR plays a key role in IFN induced-innate antiviral response, virus-induced apoptosis, cell growth & differentiation. PKR induces apoptosis by up-regulating Fas expression and mediates FADD/Caspase-8 death signaling pathway. Upon viral infection, it functions as a dual protein, sequentially activating both cell survival & cell death pathways using kinase independent and dependent strategies. PRKR regulates multiple pathways which include NF-kappaB activation, p53, p38, & PDGF signaling pathway. PKR has been implicated in tumor suppression & malignancy. To evade the antiviral effects of PKR, viruses have evolved multiple mechanisms, such as the inhibition of PKR by the non-structural protein (NS1) of the influenza virus. More recently, PKR has been implicated in several neurodegenerative diseases including Alzheimer, Huntington, and amyotrophic lateral sclerosis.
TRUSTED_SUSTAINABILITY

Specifikationer

Tillträdesnummer P19525
Koncentration See Label
För användning med (applikation) Kinase Assay
Formulering 50mM tris with 2mM DTT, 50% glycerol, 0.5mM EDTA, 150mM NaCl, 0.02% Triton X-100 and no preservative; pH 7.5
Gen-ID (Entrez) 5610
Molekylvikt (g/mol) 62.2 kDa
Namn Human EIF2AK2 (PKR), GST Tag
pH-intervall 7.5
Reningsmetod Purified
Kvantitet 10 μg
Förvaringskrav -80°C, Avoid Freeze/Thaw Cycles
Regulatorisk status RUO
Gene Alias 2310047A08Rik; 4732414G15Rik; AI467567; AI747578; double stranded RNA activated protein kinase; dsRNA-activated kinase; EC 2.7.11.1; eIF-2 alpha; eIF2a Kinase; eIF-2A protein kinase 2; EIF2AK1; EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2; eukaryotic translation initiation factor 2-alpha kinase 2; IFN- type I-induced and dsRNA-activated kinase; IFN-induced and double-stranded RNA-activated kinase; interferon-induced, double-stranded RNA-activated protein kinase; interferon-inducible elF2alpha kinase; interferon-inducible RNA-dependent protein kinase; MGC126524; OTTHUMP00000201320; P1/eIF-2A protein kinase; p68 kinase; PKR; PPP1R83; Prkr; protein kinase R; protein kinase RNA-activated; protein kinase, interferon inducible double stranded RNA dependent; Protein kinase, interferon-inducible double stranded RNA dependent; protein phosphatase 1, regulatory subunit 83; serine/threonine-protein kinase TIK; T-cell viral integration site; Tik; Tyrosine-protein kinase EIF2AK2
Vanligt namn PKR
Gensymbol EIF2AK2
KinaseFamily PEK Kinase Family
Protein Längd 252-551
Produkttyp Protein
Konjugera Unconjugated
Art Human
Rekombinant Recombinant
Protein Tag GST-tag
Sekvens 252-551
Innehåll och lagring -80°C, Avoid Freeze/Thaw Cycles
Analysinträde Biochemical terbium phospho-specific activity, Biochemical binding/kinetic
Kinase Group Ser⁄Thr Kinases: Other
Frakt skick Dry Ice
Systemkompatibilitet LanthaScreen™ Antibody, LanthaScreen™ Substrate
Målinträde EIF2AK2
Target Gene eukaryotic translation initiation factor 2-alpha kinase 2
Uttryckssystem Insect cells
Proteinfamilj Kinases & Inhibitors
Proteinform Recombinant, Catalytic
Form Liquid
Protein subtyp Serine/Threonine Kinases
Forskningskategori Signal Transduction
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