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EPPK1 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Thermo Scientific PA564412
Additional Details : Weight : 0.02000kg
Description
Immunogen sequence: ECPRDETSGL HLLPLPESAP ALPTEEQVQR SLQAVPGAKD GTSLWDLLSS CHFTEEQRRG LLEDVQEGRT TVPQLLASVQ RWVQETKL Highest antigen sequence identity to the following orthologs: Mouse - 37%, Rat - 37%.
Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress (PubMed:15671067, PubMed:27206504, PubMed:23398049). In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture (PubMed:27206504, PubMed:23398049). However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epithelium morphogenesis and integrity. In response to cellular stress, plays a role in keratin filament reorganization, probably by protecting keratin filaments against disruption. During liver and pancreas injuries, plays a protective role by chaperoning disease-induced intermediate filament reorganization.Specifications
EPPK1 | |
Polyclonal | |
Unconjugated | |
EPPK1 | |
450 kDa epidermal antigen; epidermal autoantigen 450K; EPIPL; EPIPL1; epiplakin; epiplakin 1; EPPK1 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
83481 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunocytochemistry, Immunohistochemistry (Paraffin) | |
0.2 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
P58107 | |
EPPK1 | |
Recombinant protein corresponding to Human EPPK1 | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Research Use Only