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ERK1/2 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 11257-1-AP-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16828213

  • 1656.73 SEK / 20µL
Estimated Shipment: 02-04-2024
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Description

Description

This antibody can recognize both ERK1 and ERK2 with the molecular mass of 38-43 kDa.

MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. The p44/42 MAPK (Erk1/2) are members of mitogen-activated kinases (MAPKs) of serine/threonine protein kinases. Phospho ERK1/2 can be activated by a range of extracellular stimuli, such as mitogen, growth factors, neurotransmitters, chemokines, and cytokines, through receptor tyrosine kinases (RTK), G protein-coupled receptors (GPCRs), or protein kinase C (PKC). Upstream MEK1 and MEK2 activate p44 and p42 (phospho ERK1/2) through phosphorylation of activation loop residues Thr202/Tyr204 and Thr185/Tyr187, respectively. p44/42 (ERK1/2) are negatively regulated by a family of dual-specificity (Thr/Tyr) MAPK phosphatases, known as DUSPs or MKPs, along with MEK inhibitors, such as U0126 and PD98059.
Specifications

Specifications

ERK1/2
Polyclonal
Unconjugated
MAPK1
ERK, ERK 1, ERK1, ERK1/2, ERT2, HS44KDAP, HUMKER1A, Insulin stimulated MAP2 kinase, MAP kinase 1, MAP kinase 3, MAP kinase isoform p44, MAPK 1, MAPK 3, MAPK3, p44 ERK1, p44 MAPK, P44ERK1, P44MAPK, PRKM3
Rabbit
Antigen Affinity Chromatography
RUO
26413, 26417, 5594, 5595
-20°C
Liquid
Immunofluorescence, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
0.22 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P27361, P28482, P63085, Q63844
MAPK1, MAPK3
ERK1/2 Fusion Protein Ag1759
20 μL
Primary
Human, Mouse
Antibody
IgG
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