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ERK1/2 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 11257-1-AP-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16828213

  • 1236.20 SEK / 20µL
Estimated Shipment: 30-11-2021

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Description

Description

This antibody can recognize both ERK1 and ERK2 with the molecular mass of 38-43 kDa.

MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. The p44/42 MAPK (Erk1/2) are members of mitogen-activated kinases (MAPKs) of serine/threonine protein kinases. Phospho ERK1/2 can be activated by a range of extracellular stimuli, such as mitogen, growth factors, neurotransmitters, chemokines, and cytokines, through receptor tyrosine kinases (RTK), G protein-coupled receptors (GPCRs), or protein kinase C (PKC). Upstream MEK1 and MEK2 activate p44 and p42 (phospho ERK1/2) through phosphorylation of activation loop residues Thr202/Tyr204 and Thr185/Tyr187, respectively. p44/42 (ERK1/2) are negatively regulated by a family of dual-specificity (Thr/Tyr) MAPK phosphatases, known as DUSPs or MKPs, along with MEK inhibitors, such as U0126 and PD98059.
Specifications

Specifications

ERK1/2
0.22 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P27361, P28482, P63085, Q63844
ERK, ERK 1, ERK1, ERK1/2, ERT2, HS44KDAP, HUMKER1A, Insulin stimulated MAP2 kinase, MAP kinase 1, MAP kinase 3, MAP kinase isoform p44, MAPK 1, MAPK 3, MAPK3, p44 ERK1, p44 MAPK, P44ERK1, P44MAPK, PRKM3
Rabbit
IgG
20 μL
-20°C
Primary
26413, 26417, 5594, 5595
Immunofluorescence, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
MAPK1
Liquid
MAPK1, MAPK3
ERK1/2 Fusion Protein Ag1759
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse
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