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Etoposide

Produktkod. 15495819
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Produktkod. 15495819 Leverantör Thermo Scientific Alfa Aesar Leverantörsnummer J63651.MB
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Beskrivning

Topoisomerase inhibitor and inducer of apoptosis | CAS: 33419-42-0 | C29H32O13 | 588.56 g/mol

Etoposide is used as a inhibits DNA synthesis and is very active against cells in the late S and G2 phases of the cell cycle. Etoposide was reported to be used to serum starve Saos-2 M5(p53-/-) cells which were transfected by electroporation with indicated expression plasmids for flag-E2F1 and myc-EBNA3C for selection of colony forming units, thus studying the blocking effect of EBV Nuclear Antigen 3C on E2F1 Mediated Apoptosis Induced by the DNA Damage Response.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Etoposide is used as a inhibits DNA synthesis and is very active against cells in the late S and G2 phases of the cell cycle. Etoposide was reported to be used to serum starve Saos-2 M5(p53-/-) cells which were transfected by electroporation with indicated expression plasmids for flag-E2F1 and myc-EBNA3C for selection of colony forming units, thus studying the blocking effect of EBV Nuclear Antigen 3C on E2F1 Mediated Apoptosis Induced by the DNA Damage Response.

Solubility
Insoluble in water.

Notes
Store solutions in DMSO at 4°C. For long term storage prepare aliquots and store at -20°C.
TRUSTED_SUSTAINABILITY

Kemiska identifierare

CAS 33419-42-0
Molekylformel C29H32O13
Molekylvikt (g/mol) 588.56
MDL-nummer MFCD00869325,MFCD00869325
InChI-nyckel VJJPUSNTGOMMGY-MRVIYFEKSA-N
Synonym vjjpusntgommgy-nzlmilqcsa
PubChem CID 50936917
IUPAC-namn (10R,11R,15R,16S)-16-{[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-hexahydro-2H-pyrano[3,2-d][1,3]dioxin-6-yl]oxy}-10-(4-hydroxy-3,5-dimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0³,⁷.0¹¹,¹⁵]hexadeca-1,3(7),8-trien-12-one
LEDER COC1=CC(=CC(OC)=C1O)[C@H]1[C@@H]2[C@H](COC2=O)[C@H](O[C@@H]2O[C@@H]3CO[C@@H](C)O[C@H]3[C@H](O)[C@H]2O)C2=CC3=C(OCO3)C=C12

Specifikationer

Kemiskt namn eller material Etoposide
Smältpunkt 236°C to 251°C
Färg White
Kvantitet 25 mg
Merck Index 14,3886
Löslighetsinformation Insoluble in water.
Optisk rotation −107° (c=1 in Methanol/Dichloromethane 1:9)
Formel vikt 588.56
Fysisk form Powder

RUO – Research Use Only

Produkttitel
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