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Tocris Bioscience™ Evofosfamide

Produktkod. 18063902
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Produktkod. Kvantitet
18063902 10 mg
18004052 50 mg
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Produktkod. 18063902 Leverantör Tocris Bioscience™ Leverantörsnummer 7507/10

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Beskrivning

Hypoxia-activated DNA alkylating agent prodrug

Evofosfamide is a hypoxia-activated prodrug of the cytotoxin bromo-isophosphoramide mustard (Br-IPM). Evofosfamide is stable under normoxic conditions but is activated by cellular reductases in hypoxic conditions (IC50 values are 5.1 μM and 0.019 μM, in NSCLC cells under normoxic and hypoxic conditions, respectively). Br-IPM acts as a DNA alkylating agent, inducing intrastrand and interstrand crosslinks. Evofosfamide inhibits NEPC PDX tumor growth by 84.5% in adeno-CRPC and NEPC patient-derived xenograft models. When combined with gemcitabine (Cat. No. 3259), Evofosfamide inhibits primary tumor growth by 96% and significantly extends the survival time in the MIA PaCa-2 human pancreatic cancer orthotopic xenograft model.
TRUSTED_SUSTAINABILITY

Specifikationer

Kemiskt namn eller material (1-Methyl-2-nitro-1H-imidazol-5-yl)methyl N,N'-bis(2-bromoethyl)phosphorodiamidate
CAS 918633-87-1
Kvantitet 10 mg
Mål Apoptosis Inducer Compounds
Molekylformel C9H16Br2N5O4P
Renhet 0.98
Produkttitel
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