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STEMCELL Technologies EX527

Produktkod. 17180252
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Kvantitet:
10 mg
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Produktkod. Kvantitet
17180252 10 mg
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Produktkod. 17180252 Leverantör STEMCELL Technologies Leverantörsnummer 73654

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Beskrivning

Epigenetic modifier; Inhibits SIRT1 histone deacetylase

  • EX527 is a cell-permeable, selective inhibitor of mammalian sirtuin 1 (SIRT1; IC50 = 98 nM) over SIRT2 and SIRT3 and has no effect on other histone deacetylases (HDACs; Nayagam et al.) SIRT1 is a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase with roles in energy metabolism and inflammation
  • Studies have shown that EX527 inhibits sirtuins by forming a trimeric sirtuin complex with an NAD+-derived coproduct (Gertz M et al.)
  • Increases the production of oligodendrocytes from differentiating neural stem cells and neural progenitor cells in vitro (Rafalski et al.)
  • Restores the microvascular response during the hypoinflammatory phase in a mouse model of sepsis, and enhances the systemic innate immune response (Vachharajani et al.)
  • Delays cyst growth in kidneys of PKD1 knockout mouse models (Zhou et al.)

Specifikationer

CAS 49843-98-3
Synonym Selisistat
Kvantitet 10 mg
Molekylformel C13H13ClN2O
Renhet ≥98%
Produkttitel
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