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Thermo Scientific™ EZ-Link™ TFP Ester-PEG12-DBCO

A heterobifunctional crosslinker that contains an amine reactive tetrafluorophenyl (TFP) and a dibenzylcyclooctyne (DBCO) with a water solubilizing long PEG12 spacer in between. Use to label any primary amine containing molecule such as a protein to biomolecule with a distantly attached DBCO group.

Brand:  Thermo Scientific™ C20040

1440.07 SEK valid until 2024-03-29
Use promo code "21615" to get your promotional price.



Additional Details : Weight : 0.05000kg

Product Code. 17601586

  • 2160.00 SEK / 25mg
Estimated Shipment: 22-04-2024
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Description

Description

  • A heterobifunctional crosslinker that contains an amine reactive tetrafluorophenyl (TFP) and a dibenzylcyclooctyne (DBCO) with a water solubilizing long PEG12 spacer in between the two groups
  • This crosslinker can be used to label any primary amine containing molecule such as a protein to biomolecule with a distantly attached DBCO group
  • Once a protein or (bio)molecule is DBCO labeled, it can undergo a copper-free azide-alkyne cycloaddition reaction to form a stable triazole linkage with an azide labeled coupling partner
  • Can be used to create diverse conjugates with the biorthogonal coupling between an alkyne and azide (supplied separately)
  • The coupling or crosslinking procedure is typically done in two steps:
    • First, a protein or amine containing molecule is labeled with a DBCO group and excess crosslinker is removed
    • Second, an azide containing moiety (prepared independently) is introduced into the same system as the DBCO moiety
    • Labeling occurs under biological conditions without the introduction of any additional reagents such as a copper catalyst
  • Reagent readily dissolves in water-miscible solvents for dilution into aqueous reaction mixtures
  • TFP esters are more hydrolytically stable than NHS esters
Specifications

Specifications

Amine-Azide
TFP Ester-PEG12-DBCO
Yes
Upon receipt store desiccated at -20°C.
Wet Ice
Chemical Labeling
TFP Ester, DBCO
Liquid
DMF, DMSO
No
No
1067.12
46.3 Å
Not determined
EZ-Link™
Heterobifunctional
Long (>30 Å)
25 mg
Standard
Crosslinker
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