missing translation for 'onlineSavingsMsg'
Läs mer
  1. Home
  2. Products
  3. Proteinanalysreagenser
  4. Bioaktiva små molekyler
  5. 18796636

Tocris Bioscience™ FC 11
GREENER_CHOICE

Produktkod. 18796636
Change view
Klicka för att se tillgängliga alternativ
Kvantitet:
2 mg
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Produktkod. Kvantitet
18796636 2 mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Denna artikel kan inte returneras. Se returpolicy
Produktkod. 18796636 Leverantör Tocris Bioscience™ Leverantörsnummer 7306/2

Please to purchase this item. Need a web account? Register with us today!

Denna artikel kan inte returneras. Se returpolicy

Beskrivning

Highly potent focal adhesion kinase (FAK) Degrader (PROTAC™)

FC 11 is a highly potent focal adhesion kinase (FAK) PROTAC™ Degrader (DC50 values are 40 to 370 pM depending on cell line), which is composed of the FAK inhibitor PF 562217 joined by a linker to the cereblon-binding ligand Pomalidomide (Cat. No. 6302). The effects of FC 11 are reversible upon compound wash out. FC 11 also degrades autophosphorylated FAK (pFAKtyr397), displaying near complete degradation after 3 hours at 100 nM in TM3 cells.

PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.

TRUSTED_SUSTAINABILITY

Specifikationer

Kemiskt namn eller material 1-[2-[2-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1 H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-N-[4-[[4-[[[2-[methyl(methylsulfonyl)amino]-3-pyridinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]phenyl]-1 H-1,2,3-triazole-4-carboxamid
CAS 2271035-37-9
Kvantitet 2 mg
Mål FAK
Molekylformel C41H42F3N13O9S
Renhet 0.98
Produkttitel
Välj ett problem

Genom att klicka på Skicka bekräftar du att du kan bli kontaktad av Fisher Scientific angående feedbacken du har lämnat i detta formulär. Vi kommer inte att dela din information för andra ändamål. All kontaktinformation som tillhandahålls ska också underhållas i enlighet med vår Sekretesspolicy.