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![FGFR3 [K650E] Recombinant Human Protein 10μg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-650.jpg)
FGFR3 [K650E] Recombinant Human Protein
FGFR3 [K650E] Recombinant Human Protein
Brand: Invitrogen PV4392
Additional Details : Weight : 0.00900kg
Description
FGFR3 is a member of the FGFR family of receptor tyrosine kinases. This family is known to regulate a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR family has also been implicated in a number of diseases including cancer, rheumatoid arthritis, and diabetic retinopathy. The K650E mutation leads to constitutive activation and the neonatal lethal disorder TDII.Specifications
| NP_000133; K650E | |
| Cell Structure, Pharma and Biopharma, Protein Assays and Analysis, Target and Lead Identification and Validation, Kinase Assay | |
| FGFR3 [K650E] Recombinant Human Protein | |
| –80°C | |
| 1 Each | |
| FGFR3 [K650E] Recombinant Human Protein | |
| FGF receptor | |
| FGFR3 [K650E] Recombinant Human Protein | |
| Human | |
| Baculovirus | |
| Receptor tyrosine kinases |
| 0.5mg/mL | |
| 49.8kDa | |
| 10μg | |
| For research use only. Not for use in diagnostic procedures | |
| FGFR3 K650E | |
| FGFR3 K650E was pre-diluted in enzyme dilution buffer and assayed in 25mM HEPES (pH 7.5), 10mM MgCl2,1mM EGTA, 0.5mM Na3VO4, 5mM β-glycerophosphate, 2mM DTT, 0.01% Triton™ X-100, 200μM ATP, 200μg/mL poly [Glu, Tyr] 4:1 substrate and trace [32P]-γ-ATP for 10 minutes at 30°C | |
| Amino acids 398-806; K650E | |
| 879nmoles of phosphate transferred to poly [Glu, Tyr] 4:1 substrate per minute per mg of total protein at 30°C. Activity determined at a final protein concentration of 2μg/mL | |
| His Tag | |
| Kinase and inhibitors | |
| 75% by SDS-PAGE |
For Research Use Only. Not for use in diagnostic procedures.