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Invitrogen™ Human FGFR3 [K650M], GST Tag, His Tag Recombinant Protein

Produktkod. 15438863
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Kvantitet:
1 mg
10 μg
100 μg
Förpackningsstorlek:
100µg
10µg
1mg
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Produktkod. 15438863

Brand: Invitrogen™ PV6189

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Beskrivning

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Human FGFR3, C-terminal fragment, amino acids R397-T806 (as in NCBI/Protein entry NP_000133.1) with a K650M mutation, N-terminal GST-HIS6 fusion protein with a 3C cleavage site, expressed in Sf9 insect cells. , Validated in LanthaScreen™ Kinase Binding Assay, Protocols available for simple use and optimized performance, Multiple pack sizes available for convenient use Related Product: LanthaScreen™ Eu Kinase Binding Assay Protein Form: Recombinant

This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.
TRUSTED_SUSTAINABILITY

Specifikationer

Koncentration See Label
För användning med (applikation) Kinase Assay
Formulering 50 mM HEPES with 100 mM NaCl, 15 mM glutathione, 20% glycerol, 5 mM DTT and no preservative; pH 7.5
Molekylvikt (g/mol) 73.9 kDa
Namn Human FGFR3 [K650M], GST Tag, His Tag
Kvantitet 1 mg
Vanligt namn FGFR3 (K650M Mutant)
Protein Längd 397-806
Konjugera Unconjugated
Art Human
Rekombinant Recombinant
Protein Tag GST-tag, His-tag
Innehåll och lagring -80°C, Avoid Freeze/Thaw Cycles
Uttryckssystem Insect cells
Form Liquid
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