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Fibronectin Mouse anti-Human, Clone: FN-3, eBioscience™

Mouse Monoclonal Antibody

984.00 SEK - 2265.00 SEK

Specifications

Antigen Fibronectin
Clone FN-3
Target Species Human
Conjugate Unconjugated
Isotype IgG1
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15228197
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Affymetrix eBioscience
14-9869-80
25 μg
984.00 SEK
25µg
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Estimated Shipment
12-02-2021
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15238197
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Affymetrix eBioscience
14-9869-82
100 μg
2265.00 SEK
100µg
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Estimated Shipment
01-03-2021
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Description

Description

Fibronectin is a disulfide-bonded dimer with a molecular weight range of 230-250 kDa. In the extracellular matrix of several connective tissues and vessels, fibronectin is present as an insoluble protein that is extensively cross-linked by interchain disulfide bonds forming high molecular mass polymers. Fibronectin is most abundant during embryonic development and tissue remodeling. Fibronectin is also present at high concentrations as a soluble plasma protein. Fibronectin is organized as a linear series of repeating modules which form domains for interaction with fibronectin itself, other matrix components (e.g. collagen and heparin) and receptors on cells (e.g. integrins). Fibronectin is present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. Fibronectin has been implicated in carcinoma development in lung cancer. Further, Fibronectin expression is increased especially in non-small cell lung carcinoma. The adhesion of lung carcinoma cells to Fibronectin enhances tumorgenecity and confers resistance to apoptosis induced by standard chemotherapeutic agents. The gene encoding Fibronectin has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some Fibronectin variants has not been determined.
Specifications

Specifications

Fibronectin
Human
IgG1
Monoclonal
Liquid
Antibody
4° C
FN-3
Unconjugated
Immunohistochemistry (Paraffin), Western Blot
Primary
Monoclonal
PBS with 0.09% sodium azide; pH 7.2
RUO
SDS

For Research Use Only.